Background: Crouzon syndrome ([OMIM] #123500) caused by FGFR2 mutation is an autosomal dominant syndrome with craniosynostosis, the underlying mechanism of which remains obscure.Methods: First, whole exome sequencing was used to screen the possible pathogenic variant in two sporadic patients with Crouzon syndrome.The investigation of primary and se
Delirium is a serious and complex problem facing critically ill patients.This retrospective study aimed to explore the association between prognostic nutrition index (PNI) and delirium in critically ill patients in the intensive care unit (ICU).This study was based on the Medical Information Mart Intensive Care IV (MIMIC IV) database.Patients over
Bladder cancer is the ninth most frequent-diagnosed disease worldwide, bearing high morbidity and mortality rates.Studies have shown that a particular population of CXCR5+CD8+ T cells was associated with superior prognosis in various tumor types, and yet its role in muscle-invasive bladder cancer (MIBC) remains unclear.In this study, 662 MIBC patie
In this paper, we report the complete mitochondrial genome of an Australian little penguin (Eudyptula minor Electric Range novaehollandia).The mitogenome sequence has been found to be circular, and 17,608 bp in length.Similar to other Spheniscidae species, the genome encoded a typically conserved structure consisting of 13 protein-coding genes (PCG